Krystle Kalafut*, Morgan Janes, and Francesca Riccio-Ackerman
Edited by Ekaterina Titarenko and Grant A. Knappe
Article | Aug. 29 2022
*Email: kkalafut@fas.harvard.edu
DOI: 10.38105/spr.d97k21lnkj
Highlights
- The number of individuals above the age of 65 is increasing around the world, and an estimated one in four Americans will be aged 65 years or older by 2060
- The ongoing demographic shift presents a public health challenge due to the increased risk of chronic diseases in older adults, necessitating adaptations to the current healthcare system
- Research in the field of geroscience has identified a set of core underlying biological features of the aging process, referred to as the “hallmarks of aging”
- Several promising interventions targeting the hallmarks of aging, including dietary restriction, as well as drugs approved for other disease indications, have been successful in extending health in animal models
- Efforts to identify reliable biomarkers of the aging process, define the indication for use of geroscience-guided therapies, and determine appropriate clinical trial design will be instrumental in the translation of novel therapies to improve healthy longevity in humans
Article Summary
Open Access

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Krystle Kalafut
Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, United States
Morgan Janes
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States
Francesca Riccio-Ackerman
Biomechatronics Group, Media Lab, Massachusetts Institute of Technology, Cambridge, MA
K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA