Anna M. Romanov* and Jeongpyo Hong
Edited by Steven S. Cheng and Grant A. Knappe
Article | Aug. 29 2022
*Email: romanov@mit.edu
DOI: 10.38105/spr.6zwl7hims5
Highlights
- Human challenge trials are advantageous for studying emerging disease and vaccine efficacy but have a controversial history
- Challenge trials for COVID-19 began in 2021 and invigorated the debate around the ethics of intentionally exposing trial participants
- Few regulations currently exist for challenge agents, possibly limiting implementation in future epidemics
Article Summary
Open Access

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Anna M. Romanov
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
Jeongpyo Hong
Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston, MA, USA